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| Mechanical Feedback in the Drosophila melanogaster Embryo: Robustness and Intercellular Coordination |
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| Content: |
Successful embryonic development of any organism hinges on multiple morphogenetic processes working seamlessly in concert and requires both cellular coordination and the ability to continue development in spite of perturbations. We believe that this coordination and robustness are largely accomplished through intricate intercellular communication via mechanical stress fields and through associated feedback mechanisms. The importance of chemical signaling to biological development is undeniable; however, mechanical stress has been shown to play an important role in the sculpting of developing tissues. Systematic methods of studying the harmonization of cellular activities through mechanical stress and feedback within a tissue have yet to be developed. Motivated by the need for such methods, we introduce two novel modeling platforms which successfully capture different aspects of ventral furrow formation during the gastrulation of a Drosophila melanogaster embryo. Both modeling platforms represent cells as mechanically excitable objects which experience pairwise interactions; however, the first considers cells to be fully three dimensional, soft, non-spherical objects while the second hones in on the outer surface by simplifying cells into discs. Using both of these models we explore how mechanical feedback can facilitate the robustness of ventral furrow formation, the initiating morphogenetic process of gastrulation in the Drosophila embryo. |
| Id: |
1 |
| Place: |
Science Building Texas Tech University, Physics & Astronomy Department, Box 41051, Lubbock, TX 79409-1051
Room: 103/106 - board #: G4-2 |
| Starting date: |
| 06-Oct-2017 |
14:00 (America/Chicago) |
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| Duration: |
02h00' |
| Primary Authors: |
Mr. HOLCOMB, Michael (TTU Department of Physics and Astronomy) |
| Co-Authors: |
Dr. BLAWZDZIEWICZ, Jerzy (TTU Department of Mechanical Engineering)
Dr. GAO, Guo-Jie Jason (Shizuoka University Department of Mathematical and Systems Engineering)
Dr. THOMAS, Jeffrey (TTUHSC Department of Cell Biology & Biochemistry) |
| Presenters: |
Mr. HOLCOMB, Michael |
| Material: |
 Poster |
| Included in session: |
Group 4 |
| Included in track: |
Graduate students poster competition |
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